Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases
نویسندگان
چکیده
منابع مشابه
Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as an IL-11 antagonist.
We have expressed a soluble N-glycosylated form of the murine interleukin-11 (IL-11) receptor alpha-chain (sIL-11R) and examined signaling in cells expressing the gp130 molecule. In the presence of gp130 but not the transmembrane IL-11R, the sIL-11R mediated IL-11-dependent differentiation of M1 leukemic cells and proliferation in Ba/F3 cells. Early intracellular events stimulated by the sIL-11...
متن کاملInterleukins-6 and -11 expression in primary breast cancer and subsequent development of bone metastases.
Breast cancers frequently metastasize to bone where they often cause extensive tumor-induced osteoclast-mediated osteolysis. Interleukin-6 (IL-6) and IL-11 are two cytokines exhibiting osteolytic properties through their potent stimulation of osteoclast formation. We investigated the expression of IL-6 and IL-11 in 99 invasive primary breast tumors by immunohistochemistry and in situ hybridizat...
متن کاملIdentification of MicroRNAs Inhibiting TGF-β-Induced IL-11 Production in Bone Metastatic Breast Cancer Cells
Development of bone metastases is dependent on the cancer cell-bone cell interactions in the bone microenvironment. Transforming growth factor β (TGF-β) is released from bone during osteoclastic bone resorption and induces production of osteolytic factors, such as interleukin 11 (IL-11), in breast cancer cells. IL-11 in turn increases osteolysis by stimulating osteoclast function, launching a v...
متن کاملIIIIII 11111 lll Il Il 11 Il 11 Il
[73] Assignee: The United States of America as Vector Processor Architecture for Real-Time Control”, IEEE, Nov. 1989. Ling et al., A VLSI Robotics Vector Processor For Real-Time Control; IEEE, 1988. Amin-Javaheri et al., “Systolic Architecture for the Manipulator Inertia Matrix”, IEEE Dec. 1988. Fijany et al., “A Class of Parallel Algorithms for Computation of the Manipulator Inertia Matrix”, N...
متن کاملIl 11 l 111111 Ill Il 11 Il 11 III 11111 111 11111 11 ll III 11111111111111 Il
Lipcznska-Kochany et al. Charge-transfer complexation with a new class of electron acceptors made of a tryptycenequinone unit. Chemistry Letters (1982), (7), pp 1075-8 (abstract).* P. Bartlett et al., Triptycene (9,l&o-Benzenoanthracene), J. Am. Chem. SOC. 64:2649-53, 1942. P. Bedworth et al., The Synthesis of a symmetrically substituted a-octa(isopentoxy)anthralocyanine, J. Chem. SOC. Chem. Co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomedicines
سال: 2021
ISSN: 2227-9059
DOI: 10.3390/biomedicines9060659